The severity of prolactin-related symptoms from risperidone treatment for schizophrenia decreased with a reduction in dosage, suggesting a need to track hyperprolactinemia during long-term risperidone treatment, according to a recent article in BMC Psychiatry. The investigators randomly assigned patients with schizophrenia into 3 groups: participants continued their initial optimal therapeutic dose of risperidone until one-year follow-up; participants took the initial dose for 4 weeks; and participants took it for 26 weeks. The patients, average age 32, were treated at 19 mental health centers in China between December and January
Antipsychotics, as their name implies, are an important part of treating psychosisa mental state often associated with schizophrenia and bipolar disorderthough they can also be prescribed for conditions such as severe depression, obsessive compulsive disorder OCDand post-traumatic stress disorder PTSD. But, as with any drug, these medications can come with some side effects that aren't necessarily obvious. In general, antipsychotics primarily work by blocking or suppressing the brain's dopamine D2 receptorwhich is thought to be associated with symptoms of psychosis, Ananda PandurangiPh.
Medically reviewed by Drugs. Last updated on Dec 19, Commonly reported side effects of risperidone include: agitation, akathisia, anxiety, constipation, dizziness, drowsiness, dystonia, extrapyramidal reaction, nausea, rhinitis, and weight gain.
Sexual dysfunction is a common condition in patients taking antipsychotics, and is the most bothersome symptom and adverse drug effect, resulting in a negative effect on treatment compliance. It is known that hyperprolactinemia is a major cause of sexual dysfunction. Based on the blockade of dopamine D2 receptors, haloperidol, risperidone, and amisulpride are classed as prolactin-elevating antipsychotics, while olanzapine, clozapine, quetiapine, ziprasidone, and aripiprazole are classed as prolactin-sparing drugs. Risperidone and the other typical antipsychotics are associated with a high rate of sexual dysfunction as compared to olanzapine, clozapine, quetiapine, and aripiprazole.
With the advent of newer antipsychotic drugs, side effects such as sexual dysfunction have been a major contributor toward treatment compliance. There are only a few studies that have compared different atypical antipsychotic agents regarding sexual dysfunction. We have not come across any data in this area on Indian population.
A systematic review on clinical management of antipsychotic-induced sexual dysfunction in schizophrenia. Address for correspondence. The aim of this study was to review and describe clinical findings relating to the appropriate management of such dysfunctions.
ANN M. Related Editorial. The use of antipsychotic medications entails a difficult trade-off between the benefit of alleviating psychotic symptoms and the risk of troubling, sometimes life-shortening adverse effects.
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